Creative activities in music – A genome-wide linkage analysis. Open access logo Link logo PDF logo

Kuusi Tuire; Oikkonen, J., Kuusi, T., Peltonen, P., Raijas, P., Ukkola-Vuoti, L., Karma, K., Onkakmo, P. & Järvelä, I.

PLoS ONE Volume 11, Issue 2

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Creative activities in music represent a complex cognitive function of the human brain, whose biological basis is largely unknown. In order to elucidate the biological background of creative activities in music we performed genome-wide linkage and linkage disequilibrium (LD) scans in musically experienced individuals characterised for self-reported composing, arranging and non-music related creativity. The participants consisted of 474 individuals from 79 families, and 103 sporadic individuals. We found promising evidence for linkage at 16p12.1-q12.1 for arranging (LOD 2.75, 120 cases), 4q22.1 for composing (LOD 2.15, 103 cases) and Xp11.23 for non-music related creativity (LOD 2.50, 259 cases). Surprisingly, statistically significant evidence for linkage was found for the opposite phenotype of creative activity in music (neither composing nor arranging; NCNA) at 18q21 (LOD 3.09, 149 cases), which contains cadherin genes like CDH7 and CDH19. The locus at 4q22.1 overlaps the previously identified region of musical aptitude, music perception and performance giving further support for this region as a candidate region for broad range of music-related traits. The other regions at 18q21 and 16p12.1-q12.1 are also adjacent to the previously identified loci with musical aptitude. Pathway analysis of the genes suggestively associated with composing suggested an overrepresentation of the cerebellar long-term depression pathway (LTD), which is a cellular model for synaptic plasticity. The LTD also includes cadherins and AMPA receptors, whose component GSG1L was linked to arranging. These results suggest that molecular pathways linked to memory and learning via LTD affect music-related creative behaviour. Musical creativity is a complex phenotype where a common background with musicality and intelligence has been proposed. Here, we implicate genetic regions affecting music-related creative behaviour, which also include genes with neuropsychiatric associations. We also propose a common genetic background for music-related creative behaviour and musical abilities at chromosome 4.

Speculative Futures in the Time of Debt PDF logo

Adkins Lisa

Sociological Review

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Memorable Experiences with Sad Music : Reasons, Reactions and Mechanisms of Three Types of Experiences Open access logo Link logo PDF logo

Eerola, Tuomas;Peltola, Henna-Riikka

PLoS ONE Volume 11, Issue 6

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Reactions to memorable experiences of sad music were studied by means of a survey administered to a convenience (N = 1577), representative (N = 445), and quota sample (N = 414). The survey explored the reasons, mechanisms, and emotions of such experiences. Memorable experiences linked with sad music typically occurred in relation to extremely familiar music, caused intense and pleasurable experiences, which were accompanied by physiological reactions and positive mood changes in about a third of the participants. A consistent structure of reasons and emotions for these experiences was identified through exploratory and confirmatory factor analyses across the samples. Three types of sadness experiences were established, one that was genuinely negative (Grief-Stricken Sorrow) and two that were positive (Comforting Sorrow and Sweet Sorrow). Each type of emotion exhibited certain individual differences and had distinct profiles in terms of the underlying reasons, mechanisms, and elicited reactions. The prevalence of these broad types of emotional experiences suggested that positive experiences are the most frequent, but negative experiences were not uncommon in any of the samples. The findings have implications for measuring emotions induced by music and fiction in general, and call attention to the non-pleasurable aspects of these experiences.

‘The Rhino Horn on Display Has Been Replaced by a Replica’:Museum Security in Finland and England Open access logo PDF logo

Grove, Louise; Thomas, Suzie

Journal of Conservation and Museum Studies Volume 14, Issue 1

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Teaching Intercultural Competence in Translator Training

Tomozeiu Daniel, Koskinen Kaisa, d'Argancelo Adele

The Interpreter and Translator Trainer Volume 10, Issue 3, Pages 251–267

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Nazi memorabilia, dark heritage and treasure hunting as “alternative” tourism:Understanding the fascination with the material remains of World War II in Northern Finland Link logo

Thomas, Suzie; Seitsonen, Oula; Herva, Vesa-Pekka

Journal of Field Archaeology Volume 41, Issue 3, Pages 1–13

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'Hidrunisa Samora' : Invocations of a Dead Political Leader in Maputo Rap

Rantala Janne

Journal of Southern African Studies

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