Sekar, Aswin; Bialas, Allison R.; de Rivera, Heather; Davis, Avery; Hammond, Timothy R.; Kamitaki, Nolan; Tooley, Katherine; Presumey, Jessy; Baum, Matthew; Van Doren, Vanessa; Genovese, Giulio; Rose, Samuel A.; Handsaker, Robert E.; Daly, Mark J.; Carroll, Michael C.; Stevens, Beth; McCarroll, Steven A.; , ; Paunio, Tiina
Volume 530, Issue 7589, Pages 177–183, DOI: 10.1038/nature16549
Статья на конкурс «био/мол/текст»: Шизофре
Opinion: Recent high-profile donations and initiatives highlight the private control of publicly funded biomedical research. The post If Billionaires Fund Your Research, Don't Take Public Money appeared first on WIRED.
Above: Scanning electron micrograph of microglia (white, indicated by black arrows) surrounding neuronal processes. From [Couturier 2011, Figure 1] via OPENi.
Microglia, as the name suggests, are considered glial cells. Glia are a broad category, basica
The Mental Elf, 01.06.2016
Mandy Johnstone writes her debut Mental Elf blog on a recent Nature study, which identifies a set of genetic variations that are strongly associated with the risk of developing schizophrenia.
The post Schizophrenia risk and the complement C4 gene appeared
Princeton Election Consortium, 26.04.2016
I will comment on the East Coast primaries at the end of the post. First I will write about something more interesting: Google Correlate!
In human genetics there is a form of analysis called a genome-wide association study (“GWAS”)
Big Think, 15.04.2016
Wonder how your brain makes space for new memories? Scientists at Oxford just discovered how. Read More
Pharmaceutical Intelligence, 05.04.2016
Schizophrenia, broken-links Larry H. Bernstein, MD, FCAP, Curator LPBI Runs in the Family New findings about schizophrenia rekindle old questions about genes and identity. BY SIDDHARTHA MUKHERJEE Annals of Science MARCH 28, 2016 ISSUE &n
Mad In America, 21.03.2016
The March 3rd, 2016 edition of the Wall Street Journal featured an article by past President of the American Psychiatric Association (APA) Jeffrey Lieberman and his colleague, computational neuroscientist Ogi Ogas. The article was entitled “Genetics
Brain Blogger, 13.03.2016
The discovery of a runaway gene is being touted as one of schizophrenia’s greatest breakthroughs. Researchers have discovered a gene that prunes away communication infrastructure in the brain, and when this gene prunes too much, schizophrenia can dev
Stacey GabrielStacey is the Director of the Genomics Platform at the Broad Institute. Gave us a brief look back to 2006: 117 instruments (GA's) producing 600,000 bases per day and 1 genome, versus 30 machines producing 12,000,000,000,000 bases per day and
Mad In America, 06.02.2016
Another scientific study that ostensibly identifies a biological cause of schizophrenia has appeared and is being widely reported. According to the Los Angeles Times (1/27/16, emphases added):
"Scientists say they have broken new ground in the study
Slate Articles, 05.02.2016
This article was adapted from an essay in Issues in Science and Technology.
Mad In America, 03.02.2016
On January 27, 2016, a study1 was published online in the prestigious journal Nature that touted the possibility of discovering some potential biological origins of an "illness" called "schizophrenia" (See note at the end). Subsequently, headlines across t
Genetic Literacy Project, 03.02.2016
The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion and analysis. Schizophrenia can present itself with any number of symptoms, from disorganized thinking or motor behavior, to hallucinations or delusions. Together
The Mermaid's Tale, 03.02.2016
The news and social media were headlining a report last week that presented some genetic findings, and even aspects of a possible causal mechanism, related to schizophrenia. As habitually skeptical readers of these daily stories, we wondered how subs
The research involved 700 people who had schizophrenia and donated their brains for research after their deaths.
NIH Research Matters, 02.02.2016
Scientists identified the mechanism behind genetic variations that had been linked to schizophrenia in previous studies. The findings might lead to new clinical approaches.
Discover Top Stories, 01.02.2016
A press-release from the Harvard-MIT Broad Institute reaches astonishing heights of hyperbole in announcing a new schizophrenia study (Sekar et al. 2016). Here's the release:
Genetic study provides first-ever insight into biological origin of schizophrenia
Counsel & Heal : Top News, 31.01.2016
A breakthrough study has revealed how some genes can affect the development of Schizophrenia, a complicated psychiatric condition that the scientists have spent years in understanding
Punnett's Square, 31.01.2016
Recently, scientists took a significant step toward finding the cause of schizophrenia, in a study that provides the first rigorously tested insight into the genetics behind any common psychiatric disorder. Schizophrenia is a psychiatric disorder character
La schizophrénie est une maladie complexe dont les origines sont restées jusqu’ici insaisissables. Mais le mystère s’est éclairci cette semaine quand une nouvelle étude, basée sur l’a
Shots - Health News, 29.01.2016
C4 proteins (green) are seen at the synapses in a culture of human neurons. (Heather de Rivera/McCarroll Lab/Harvard via AP)
Heather de Rivera/AP
Momma Data: Debunking Children's Health News, 29.01.2016
Two promising developments this week...schizophrenia research goes CSI and postpartum depression screening gets a thumbs up. First, a new study finds a gene that might play a role in schizophrenia. After perusing the genomes of more tha
January is just about over, and for biotech investors, that’s a good thing. The Nasdaq Biotechnology Index (NASDAQ: IBB) has plummeted more than 22 percent in January. Thursday alone the index fell more than 3.6 percent without any clear negative
Mental Floss, 29.01.2016
Scientists at Harvard Medical School have uncovered important clues about a potential cause of schizophrenia.
Pharmaceutical Intelligence, 28.01.2016
Mindful Discoveries Larry H. Bernstein, MD, FCAP, Curator LPBI Schizophrenia and the Synapse Genetic evidence suggests that overactive synaptic pruning drives development of schizophrenia. By Ruth Williams | January 27, 2016 … more follows) h
IFLScience - The Brain, 28.01.2016
The presence of certain proteins caused by the expression of a variation of a gene called C4 may be a major cause of schizophrenia. Twin Design/Shutterstock
The biological process resulting in the development of sc
Schizophrenia is a devastating and often destructive mental disorder, one that overtakes a young mind and sends it spinning out of touch with reality. About one in 100 Americans is estimated to have schizophrenia, and although the word itself has been arou
C4 (in green) located at the synapses of human neurons. (Courtesy Heather de Rivera, McCarroll lab)A deep genetic analysis, involving nearly 65,000 people, finds a surprising risk factor for schizophrenia: variation in an immune molecule best known for its
A landmark study, based on genetic analysis of nearly 65,000 people, has revealed that a person’s risk of schizophrenia is increased if they inherit specific variants in a gene related to “synaptic pruning” — the elimination of conn
Schizophrenia is a complex disease with elusive origins, but the mystery became much clearer today, when a landmark new study based on genetic analysis of nearly 65,000 individuals pinpointed a specific gene and biological process behind it. Read more...
Sydney and her mother Lori look into the bedroom mirror where Sydney experienced her first symptoms of schizophrenia. Now 20, Sydney has had no symptoms for almost two years now. (Jesse Costa/WBUR)
One November day in her senior year of high school, Sydney
Science | KQED Public Media for Northern CA, 27.01.2016
Scientists pursuing the biological roots of schizophrenia have zeroed in on a potential factor — a normal brain process that gets kicked into overdrive. The finding could someday lead to ways to treat the disease or even prevent it.
The result &mdash
b r a i n s t o r m, 30.12.2015
It’s New Year’s Eve, 2015, and I’ve just made a resolution to read a paper a day in 2016. That’s an extra 366 papers in 2016. You can follow the twitter hashtag #366papers. Happy New Year everyone. I hope 2016 is
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